- Hemoglobin A1c >= 10% and/or diabetic end organ damage (eg. neuropathy, retinopathy)
- History of Non-arteritic Anterior Ischemic Optic Neuropathy
- History of Heart Attack
- History of Stroke (CVA) and/or TIA
- History of Valvular Replacement or Disease
- History of Peripheral Vascular Disease
- End-stage kidney and/or liver disease
- Sickle Cell